EGFR and non-small cell lung carcinoma: Recently, many new facets emerged, highlighting the fact that EGFR mutations may be potentially targeted even with drugs without a peculiar EGFR action, such as bisphosphonates [19] and ibrutinib (a Bruton tyrosine kinase and BMX inhibitor) [20], that have demonstrated activity in EGFR-mutant NSCLC cell lines, including erlotinib-resistant tumors.