A recent meta-analysis confirmed that EGFR mutant NSCLC patients derived a significant progression-free-survival (PFS) advantage from TKIs over platinum-doublet chemotherapy as first-line treatment, although a significant differential benefit may be observed according to smoking status (HR for never-smokers 0.29 versus 0.54 for ever-smokers; p < 0.007) and to the type of EGFR mutation (HR for exon 19 deletion 0.25 versus 0.44 for exon 21 substitution; p < 0.001) [6]. Here, EGFR is linked to non-small cell lung carcinoma.