In contrast, all of the other characteristics, including older age, a later year of diagnosis, continued married status, a higher family income, living in a metropolitan area, a tumor on the right side, a tumor size of 0-2 cm, a negative LN status, higher differentiation, ER and PR positivity, increased acceptance of lumpectomy and receipt of radiation therapy, were independently associated with increased BCSS (Table 2), according to univariate and multivariate analyses. This evidence concerns the gene ESR1 and neoplasm.