The following pathways had more than 5 genes associated with them when up-/down-regulated genes were considered simultaneously: the Huntington’s disease pathway (P00029), the cytoskeletal regulation by Rho GTPase pathway (P00016), the inflammation mediated by chemokine and cytokine signalling pathway (P00031), the nicotinic acetylcholine receptor signaling pathway (P00044), the Alzheimer’s disease-presenilin pathway (P00004), the Cadherin signaling pathway (P00012), the Wnt signaling pathway (P00057) and the ATP synthesis pathway (P02721) (Figure 6 G). This evidence concerns the gene CDH17 and Alzheimer disease.