CLPB and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Lastly, it is interesting that the mutations causing PEPD are mostly located on the C-terminal half of the SCN9 protein, as commonly seen in the present family, whereas those related to Dravet syndrome/febrile convulsions are located on the N-terminal half (Figure 4C).