The result of our study is in good agreement with the recent study of Ray and co-workers [61] where human neuroblastoma SK-N-SH cells treated with 10 μM memantine decreased the measured levels of secreted total APP (sAβPP), APPα isoform and Aβ(1–40) in a time dependent manner for up to 24 h. This evidence concerns the gene APP and neuroblastoma.