1999; Schreuder and Nauta 2007; Bongartz et al. 2010) and that elements of the mechanism which drives the long-term response to maternal undernutrition are sex-specific. We hypothesized that accelerated, age-related progression of renal injury is ovarian hormones-dependant. We also propose that the change in the AGTR2 protein expression might be linked with it. Estrogen has been associated with increased resistance to hypertension and slower kidney aging in female subjects (Bongartz et al. 2010). This evidence concerns the gene AGTR2 and Hypertension.