Platelet hyperactivity and a concurrent increased risk in thrombotic complications are often reported in patients with obesity, type 2 diabetes mellitus (T2DM), polycystic ovary syndrome, high blood pressure, and abnormal cholesterol levels.2–4 One of the common factors in these diseases is insulin resistance, a condition where cells have a reduced ability to respond to insulin. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.