In previously study, we found 9 common activating EGFR gene mutations (six L858R substitutions and three deletion in exon 19; 6.29 % of studied group), 3 primary T790 M substitution in EGFR gene (2.1 %of studied group), three S768R substitutions in DDR2 gene (2.1 % of studied group) and one insertion in HER2 gene (0.67 % of studied group) in CNS metastases of NSCLC. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.