VPS45 and viral infectious disease: Among them, 22 genes (Gm26130, mt-Ts2, Mgst2, Cyp7a1, Vps45, etc.)were clustered as a hot block next to a block containing Irf7 gene that is the master regulator for the induction of type I interferon during viral infection (Honda et al., 2005) (S4 Fig).