For our study, the frequencies of G/G, G/A, and A/A genotypes of -2518G/A polymorphism in MCP-1 gene was analyzed by RFLP analysis and the result showed different proportion (P-value = 0.016, odd ratio (OR) = 0.693) between PCOS and control groups. The gene discussed is CCL2; the disease is polycystic ovary syndrome.