Fig 2A shows that the significantly differentially methylated loci (DML) overlap the promoter regions of transcript variant 2, 3 and 6. The identified GWAS SNP (dbSNP ID = rs11984075; RA association P-value = 5.00E-08) is A to G variant and overlaps intron 1 of transcript variant 1 [27]. Based on these data, we subsequently evaluated whether ELMO1 contributes to pathogenic behavior of RA FLS. Here, ELMO1 is linked to rheumatoid arthritis.