Other top pathways were activated only locally at the site of infection, including IFNγ, TCR, STAT3 (not on the top pathway list at Day 4; Z score 2.459, P value 1.72 x 10–19; S4 Table), TREM1 (not on the top pathway list at day 7; Z score 2.242, P value 8.72 x 10–21; S6 Table), JUN (not on the top pathway list at day 7; Z score 2.910, P value 9.77 x 10–16; S6 Table), and IL-27 (not on the day 1 top activated pathway list; Z score 2.168, P value 3.6 x 10–16; S2 Table). Here, TREM1 is linked to infection.