SYP and medulloblastoma: The synaptic vesicle protein Synaptophysin (SYP) and the microtubule-associated protein MAP2 are both expressed in Ptch1Δ/+ medulloblastomas [20,21], but not in the cerebellar nodules of aged Ptch1Δ/+Pn-1Δ/+ mice (Fig 4C and 4D).