For examples, the integration of HBx/HBsAg genes into human TERT, CCNE1, and MLL4 has frequently been observed in HCC [16,17]; HBx-LINE integration was confirmed to promote the tumorigenicity of HCC via the activation of Wnt/β-catenin signaling [18]. The gene discussed is TERT; the disease is hepatocellular carcinoma.