As shown in Fig 5, we observed a distinct gene expression pattern in patients harboring MLL4 integration/over-expression by analyzing the unsupervised clustering of HCC genome expression data; a total of 31 genes were distinctly over expressed in the MLL4 integration samples, including LMTK3 and KISS1R, which were reported to be involved in oncogenesis. The gene discussed is KISS1R; the disease is hepatocellular carcinoma.