Furthermore, serum AFP was postive (the cutoff level of normal serum AFP is ≤20ug/L) [19]) in 72% of HCC patients with the C variant infection, compared to that in 33% of patients with the B variant infection, indicating the elevated AFP in HBV C-type patients (p = 0.052, OR = 4.99) (Table 1). This evidence concerns the gene AFP and infection.