FBN1 and Marfan syndrome: MFS patients with a severe form of fibrillin-1 gene mutation had significantly reduced LVEF (60.92±4.71 vs. 55.20±7.03%, p = 0.033, Fig 1), reduced global circumferential strain (15.00±3.16 vs. 12.33±1.95%, p = 0.01) and global area strain (26.93±4.29 vs. 23.53±3.64%, p = 0.03, Fig 2) when compared to those with a mild form of fibrillin -1 gene mutation.