However, a subset of cancers are poorly infiltrated with immune cells (i.e. at least one third of all metastatic melanomas) [28] and, consistent with recently published work patients bearing tumors, in which type I IFN–regulated genes, T cell–related genes, and PD-L1 are expressed at low levels, have comparatively poor prognosis [29,30]. This evidence concerns the gene CD274 and cancer.