Moreover, unlike our consistent observation that the % of single CD8+ T cells was always greater in tumor than in spleen, there was no significant increase of CD8 T cells in tumor (68.1%) vs. spleen (65.5%) in huPBL-NSG (−CD4) mice, suggesting that the failure to expand tumor infiltrating CD8+ T cells contributed to the lapse in tumor control. The gene discussed is CD8A; the disease is neoplasm.