In CMT rats this appears to enhance the reduced signaling of phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K)–v-Akt murine thymoma viral oncogene homolog 1 (Akt) and lower augmented mitogen-activated protein kinase kinase 1 (Mek)-mitogen –activated protein kinase (Erk), and is able to improve the differentiation of Schwann cells in CMT1A. This evidence concerns the gene MAPK1 and Charcot-Marie-Tooth disease.