These abnormalities are linked to mutations in the RyR2, located on chromosome 1q42.1–q4310, which lead to familial polymorphic ventricular tachycardia, CPVT, and arrhythmogenic right ventricular dysplasia type 2, ARVD/C. This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.