ESR1 and nervous system disorder: Necdin (NDN), an imprinted gene, is associated with Prader-Willi syndrome [55] and prostate cancer [56]; similarly, CCDC62 acts as coactivator of the estrogen receptor in prostate cancer cell lines [57]; GRIN2C, a member of the NMDA glutamate receptor family, is associated with a number of neurological disorders [58,59]; Laeverin, the gene product of FLJ90650 gene, has been found to have differential expression in the placentas from patients with pre-eclampsia [60], and methylation levels of GRB10 are correlated with birth weight [30].