A review study also reported that silybin inhibited EGFR (HER1) activation by EGF in EGFR expressing cells and involves the EGFR signaling pathway and has announced that silymarin and silybin strongly decreased cell proliferation and angiogenesis, and enhanced apoptosis in the prostate tumor xenografts, and also inhibits the EGFR pathway (32). This evidence concerns the gene EGF and prostate neoplasm.