We found that RhoGDI2 was up-regulated in 5-fluorouracil (5-FU) resistant colon cancer cells (LoVo/5-FU) and that the knockdown of RhoGDI2 expression by transfection with RhoGDI2-specific siRNA significantly increased sensitivity to 5-FU in LoVo/5-FU [4]. This evidence concerns the gene ARHGDIB and malignant colon neoplasm.