Finally, CKI gene expression analysis revealed elevated mRNA expression in malignant tumors for p16INK4a, p18INK4c, p19INK4d and p21CIP/WAF1 encoding genes, i.e. Cdkn2a, Cdkn2c, Cdkn2d and Cdkn1a, while p15INK4b and p27KIP1 encoding genes, i.e. Cdkn2b and Cdkn1b mRNA levels were unchanged between conditions (Figure 2C). This evidence concerns the gene CDKN1B and cancer.