Four months later, as he had increased pleural effusion and lymph node metastasis (Figure 2F), he was re-challenged with 250 mg/day crizotinib administered every 3 days; however, Carcinoembryonic antigen (CEA) was elevated (Figure 4). The gene discussed is CEACAM5; the disease is metastatic malignant neoplasm in the lymph nodes.