Overexpression of G2019S or WT‐LRRK2 was able to reduce the payload of chaperone‐mediated autophagy, indicating that an accumulation of α‐synuclein, and misfolded proteins in general, as seen in PD, may be a partial consequence of a LRRK2‐mediated alteration of cellular proteolytic pathways 108. Here, LRRK2 is linked to Parkinson disease.