LRRK2 and leprosy: Subsequently, many variants in LRRK2 primary structure have been identified, including dominant mutations segregating with familial PD that also occur in sporadic PD and in cancer 9, together with polymorphisms at the LRRK2 locus that increase the lifetime risk for the development of sporadic PD, but also inflammatory bowel disorder and leprosy 4, 10, 11.