TPX2 is essential for the formation of an ordered spindle and successful mitosis,[11] and its regulation by importin-α is the major component of RanGTP-mediated spindle assembly (Figure 1), a process on which cancer cells rely more heavily than other cells.[12] As the transport and mitotic roles of importin-α employ two different sites on the protein, the TPX2–importin-α interaction has potential as an anticancer target, provided selectivity for the minor site over the major site can be achieved. Here, TPX2 is linked to cancer.