LGALS9 and Sepsis: In this study we examined the role of galectin-9, a mammalian β-galactoside binding lectin, in the development of sepsis during pulmonary infection with F. novicida. We report the upregulation and extracellular release of galectin-9 during F.n. infection and its ability to amplify Francisella infection-induced inflammatory response as well as concomitant improved disease severity of Gal-9-/- mice.