The scrutiny of TCGA's RNA sequencing data for the tumour tissues indicated putative C>U RNA editing of SDHB open reading frame (ORF) at c.136, but at no other site, in 30.2%, 26.4% and 9.6% of 298 primary head and neck squamous cell carcinoma, 220 lung adenocarcinoma and 187 secondary skin cutaneous melanoma cases that were examined, respectively (Fig. 4a). Here, SDHB is linked to cutaneous melanoma.