We found that APOBEC3A causes non-synonymous RNA editing of transcripts of the APP, AP2A1, CAST, LRP10 and XPO1 genes (Fig. 5c) that are implicated in pathogenesis of Alzheimer's disease through regulation of amyloid precursor protein50, 51, 52, 53, 54. Here, AP2A1 is linked to early-onset autosomal dominant Alzheimer disease.