BECN1 and pachyonychia congenita: We also examined beclin-1, a mammalian ortholog of the yeast autophagy-related gene 6 (BECN1) protein that has been shown to have relatively high levels of localization in PC tissues (www.proteinatlas.org), in human PC xenografts after radiotherapy, with or without treatment with seaweed polyphenol fractions (Figure 11).