PTGS2 and colitis: Several reports have demonstrated that F. mume is useful for the treatment of colitis in an inflammatory bowel disease model [13] and attenuates lipopolysaccharide-induced inflammation in RAW 264.7 cells by inhibiting the production of nitric oxide, prostaglandin E2, cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6) [14].