The diagnosis of vCJD was definitively confirmed in this case by the postmortem histologic and PrPSc examinations, which demonstrated the widespread presence of florid plaques, the typical electrophoretic profile of the PrPSc (3), and the PrP immunostaining demonstrating rounded cells surrounded by short delicate processes resulting in a feathery appearance (26). Here, PRNP is linked to variant Creutzfeldt-Jakob disease.