SOX2 and neoplasm: Figure 5b shows that cotransfection of miR-145 precursor and SOX2 3'UTR reporter effectively reduced luciferase activities compared to miR-precursor control (**p<0.02). Results in Figures 5c and 5d demonstrate that transfection of miR-145 precursor resulted in the downregulated expression of the SOX2 protein in C666-1 (*p<0.05). The number and size of C666-1 tumor sphere formation were also significantly suppressed (*p<0.05).