CREBBP and nasopharyngeal carcinoma: Early studies on the gene expression profile of NPC showed that the expression of a number of Wnt signaling components, including wingless-type MMTV integration site family, member 5A (Wnt5A), Frizzled homolog 7 (FZD7), β-catenin, and CREB-binding protein (CBP) are frequently activated, and the aberrant increased expression of β-catenin is associated with poor prognosis in NPC12, 13, 14.