For example, high MRE11 expression specifically predicts improved outcome with radiotherapy, demonstrating 16% improvement in 3-year cancer-specific survival (CSS) compared with high MRE11 expression treated with cystectomy (69.9% vs 53.8% 3-year CSS, P=0.021) (Choudhury et al, 2010). The gene discussed is MRE11; the disease is cancer.