On the other hand, infection with helminths like S. mansoni leads to Th2 and Treg responses, driven by DCs among other cells, via the increase in IL-10 and/or transforming growth factor β (TGF-β) levels, and surface expression of specific costimulatory molecules like Programmed Death Ligands (PD-L1/2) and OX40 ligand (OX40L) [10,11,12,13]. Here, TNFSF4 is linked to infection.