CREB1 and non-small cell lung carcinoma: In addition, we previously showed that one of these inhibitors, 2-Naphthol-AS-E phosphate (KG-501), which directly targets the KIX domain of CBP, resulted in a disrupted CREB-CBP complex, inhibited CREB-target gene induction, and inhibited IL-1β-mediated angiogenic activity in NSCLC [10].