In this study of PC specimens, ERG overexpression showed a significant association with patient age (RR = 18.207), initial PSA level (RR = 4.3), Gleason score (RR = 39.262), perineural invasion (RR = 5.17), high-grade prostatic intraepithelial neoplasm (RR = 12.501), and BCR (RR = 8.964) (p<0.05), whereas PTEN loss exhibited a significant correlation with positive surgical margin (RR = 8.524), lymphovascular invasion (RR = 23.445), perineural invasion (RR = 24.489), and pathologic N stage (RR = 11.495) (p<0.05, Table 3). This evidence concerns the gene KLK3 and pachyonychia congenita.