SRC and non-small cell lung carcinoma: Genomic alterations in CRKL appear to be predictive of response to Src inhibitors in preclinical studies with gastric and NSCLC cell lines (Figure 2).[21] Of note, chronic myeloid leukemia (CML) cell lines have the highest levels of CRKL mRNA expression according to Cancer Cell Line Encyclopedia (data base accessed on October 20th 2014).