Overexpression of CRKL in immortalized human lung epithelial cells promoted epithelial growth factor independent proliferation.[18] Suppression of CRKL amplifications in NSCLC that harbor CRKL amplifications induced cell death.[19] Overexpression of CRKL in EGFR mutant cells induced resistant to gefitinib. The gene discussed is CRKL; the disease is non-small cell lung carcinoma.