Furthermore, cancer cells of several tumor histotype express high level and activity of pyruvate kinase (PK) M2 type (PKM2) produced by alternative splicing of the PKM gene, which catalyzes the rate-limiting step of glycolysis, controlling conversion of phosphoenolpyruvate (PEP) to pyruvate, and thus ATP generation [6, 19]. Here, PKM is linked to neoplasm.