On examining the PKC expression in a variety of BC cell lines, Lindermann et al., [128] found that the protein level of PKCα was much higher in ETS1-expressing MDA-MB-231 and MDA-MB-435 BC cells than in ETS1-deficient MCF-7 and SK-BR3 cells, whereas PKCα-deficient MCF-7 cells do not support ETS1-induced activation of the PTHrP P3 promoter strongly suggesting that PKCα may be important for ETS1 activity. This evidence concerns the gene PRKCA and breast cancer.