SERPINE1 and carcinoma: Components of the urokinase plasminogen activation system, particularly urokinase plasminogen activator (uPA, Gene symbol: PLAU; located on chromosome 10q22.2), its receptor uPAR (Gene symbol: PLAUR; located on chromosome 19q13) and inhibitor plasminogen activator inhibitor type 1 (PAI-1, Gene symbol: SERPINE1; located on chromosome 7q22.1) are proven to be associated with aggressive carcinoma.