In addition, ACA exhibited various biological activities, including inhibition of the ear passive cutaneous anaphylaxis reactions in mice, antigen-IgE-mediated TNF-alpha and IL-4 production associated with the late phase of type I allergic reactions [89], the reduction of white blood cell infiltration and IgE level in the lungs of mice administered OVA, the suppression of histopathological changes, and inhibiting expression of the various cytokines. Here, IGHE is linked to allergic disease.