On the other hand, in line L63, infected birds showed a reduction of H3K27me3 levels around ITGA1at 10 dpi and a corresponding upregulation, while there were no significant changes in chromatin marks or gene expression on THBS4 or TNR. THBS4 is a putative tumor suppressor [42] and its downregulation could be associated with increased MD-susceptibility in line L72 birds. Here, THBS4 is linked to Menkes disease.