While previous studies have mainly focused on assessing the association between the level of autoantibodies to desmogleins and disease activity and their predictive value for relapse in pemphigus [7,38,39], it remains largely unknown whether the levels of Dsg1- and Dsg3-specific autoantibodies also represent a risk factor for overall mortality in patients with PV. The gene discussed is DSG3; the disease is pemphigus.