EGF and Familial prostate cancer: While two other oncogenic signaling pathways, EGF/EGFR and ERK, were activated in mouse prostate tumors upon Klf5 deletion [9], and KLF5 could positively regulate EGFR expression and ERK activation [44,45], their changes in activity in response to KLF5 modulation were inconsistent between human prostate cancer cell lines PC-3 and DU 145 and mouse prostate tissues (Additional file 4: Figure S3).