However, tumor promotion by unacetylated KLF5 does not appear to affect angiogenesis, as the number of microvessels and the expression of HIF1α and VEGF were not affected by changes in the acetylation status of KLF5 (data not shown), and angiogenesis was not among the affected processes based on bioinformatic analysis [8]. The gene discussed is KLF5; the disease is neoplasm.