Remarkably glioma and leukemia cells harboring mutations in IDH1 or -2 cannot be maintained in culture, however we previously reported that chondrosarcoma cell lines retain these mutations [31] providing us with a model to functionally study the effects of IDH1 or -2 mutations in their naturally occurring context and to evaluate whether inhibition of mutant IDH1/2 could be a potential treatment strategy. Here, IDH1 is linked to chondrosarcoma.