IDH1 and chondrosarcoma: The mutant IDH1 chondrosarcoma cell line L835, treated with 1.5 μM AGI-5198 for 10 passages, and the mutant IDH1 cell lines HT1080 and JJ012, treated for 20 passages, did not show any difference in lysine trimethylation of these specific histone marks (Figure 5A).