Our chondrosarcoma cell line panel contained one homozygous mutant IDH2 cell line (L2975) that, contradictory to what has been shown in the anaplastic astrocytoma WHO grade III cell line IMA [35], revealed elevated levels of D-2-HG comparable to heterozygous mutant IDH1/2 cell lines. Here, IDH1 is linked to anaplastic astrocytoma.