When analyzing the different probes separately, only CpG islands probes showed hypermethylation in the chondrosarcoma cell lines with an IDH1/2 mutation (Figure 2B), whereas the shores (regions flanking the CpG islands) and shelves (regions flanking the shores) show hypermethylation in the IDH1/2 wildtype cell lines (Supplementary Figure 1B). The gene discussed is IDH1; the disease is chondrosarcoma.