SMAD3 and neoplasm: EMT is a process that exerts influence on many molecular, such as TGF-β, E-cadherin, N-cadherin Vimentin, ZEB-1, SMAD-2, SMAD-3, SMAD-7, GLI1 and GLI2; these molecules are closely associated with typical phenotype changes of EMT in tumor cell growth and metastasis [10, 16-18].