In contrast, only 1 of the 6 mice in the experiment group grew the smallest tumor on Day 33 (Figure 5A-5C) along with the obvious reduction in pulmonary metastasis (Figure 5D) in the group challenged by B16F10/GPI-IL-21 combined with B16F10-shTGF-β1 and miR200c. The gene discussed is IL21; the disease is neoplasm.