IL21 and melanoma: In conclusion, our study indicated that the enhanced antitumor immune response induced by the B16F10/GPI-IL-21 vaccine and the changed EMT-related molecular expression mediated by TGF-β1 knockdown and miR200c agomir optimized the synergism antitumor regimen in the B16F10 melanoma-bearing C57BL/6 mice.