Knockdown of PHLPP decreased the apoptosis rates in EH-GB1-shPHLPP cells (P = 0.0037 versus EH-GB1-PHLPP) and GBC-SD-shPHLPP cells (P = 0.0005 versus GBC-SD, P=0.0000 versus GBC-SD-PHLPP), suggesting that PHLPP has an activity of apoptosis induction in cancer cells (Fig. 2B). This evidence concerns the gene PHLPP1 and cancer.