With the cell proliferation experiments, we found that the viabilities of EH-GB1-PHLPP and GBC-SD-PHLPP cells were significantly decreased and those of EH-GB1-shPHLPP and GBC-SD-shPHLPP cells were increased, suggesting that PHLPP has the function to inhibit cancer cell proliferation (Fig. 2C). The gene discussed is PHLPP1; the disease is cancer.