AR and posterior cortical atrophy: With data showing mast cells could increase lncRNA HOTAIR to promote the binding of PRC2 complex (via SUZ12) to AR promoter CpG region for the suppression of AR expression, the axis of lnc-RNA-HOTAIR to→AT promoter methylation→reduced AR expression→increased PCa metastasis may represent a key mechanism to control the PCa metastasis at the later castration resistant stage.