Together, results from 4 different assays, stem/progenitor cell markers (Figure 5A), cell sorting (Figure 5B), sphere formation (Figure 5C) and interruption assay (Figure 5D), all suggest that enhanced mast cell recruitment may also be able to function through modulation of AR signaling to alter CD133+ stem/progenitor cell population in PCa cells to increase PCa cells invasion. The gene discussed is AR; the disease is posterior cortical atrophy.