The serum and synovial fluid VEGF concentrations are higher in RA patients than in osteoarthritis (OA) patients or normal controls, and the VEGF levels correlate with the RA disease activity, including factors such as erythrocyte sedimentation rate, C-reactive protein, tender and swollen joint counts, serum rheumatoid factor and quality of life [9–12]. The gene discussed is VEGFA; the disease is rheumatoid arthritis.