SH2B3 and myeloproliferative disorder: Furthermore, somatic mutations in other genes, such as TET2, DNMT3A, ASXL1, EZH2, IDH1/2, U2AF1, SF3B1, SRSF2, CBL, NF-E2, SH2B3 (LNK), CHEK2 [3], and SOCS 1, 2 and 3, IKZF, SETBP1, among others, have been found in all stages of MPN [5–9].