Based on the knowledge of CARP-1/CCAR1 pro-apoptotic signaling in diverse cancer cells, and the fact that CARP-1/CCAR1 binds with APC-2 and co-activates APC/C, while APC/C is a crucial regulator of cell cycle, led us to speculate that disruption of APC/C co-activation by CARP-1/CCAR1 could impact cell cycle progression and ultimately the growth and survival of the cells. This evidence concerns the gene APC and cancer.