Consistent with the property of CARP-1/CCAR1 to regulate apoptosis signaling, a couple of studies revealed that CARP-1/CCAR1 is downregulated in a gene expression profiles of tumors derived from rasv12/E1A-transformed MEFs [57], and in peripheral blood cells from neurodegenerative disease, Friedreich's Ataxia patients [58]. Here, CCAR1 is linked to neurodegenerative disease.