In light of the fact that APC/C plays a distinct role in various cell cycle checkpoints [62, 63] and deregulation of APC/C and its regulators and substrates has been implicated in tumor progression [64], the components of the APC/C proteome including its co-activator CARP-1/CCAR1 therefore represent attractive targets for design of cell cycle inhibitory strategies with potential for therapeutic use [65–67]. The gene discussed is APC; the disease is neoplasm.